My '78 sat for years before it was given to me. Inside of the tank looked good, being my first bike, I never looked at the carbs, just threw a new yuasa at it and some tires. I got 10 miles or so away from my house before she died. Gunk that was in the carbs was loosened by fresh gas and clogged my slow jets and a passage or two. A good cleaning with gum cutter or the like will do wonders. Also, if you are not comfortable pulling the slow jets, use a guitar string or a welder's torch tip cleaner to clean it out. Remember! Brass is soft, and you do not want to enlarge the hole! Seeing as you rode 300 miles though, I'm going to go with either rust from your tank, or a bad batch of gas from your last fill-up. That also happened to me at Daytona once, I filled up, and got a tank of mostly water!
All this assumes it is a fuel problem, and not electrical. Are you running the stock points in the ignition? If your condensers die, so does the bike. Again, this happened to me! It made me go out and get a Dyna S the next day.