A Dyna S itself shouldn't cause a problem - as the electronics don't consume much more power. However, if the coils were replaced with 3 ohm units, which draw more power, as compared to stock, or 5 ohm units, then that would put more load on the 15 ampere fuse.
Looking at the schematic, the following electrical loads are fed from the 15 Amp fuse:
- Coils;
- Parking indicator light;
- Oil pressure indicator light;
- "D" indicator light;
- "L" indicator light;
- Turn signal buzzer;
- Tail light (via master cylinder switch);
- Tail light (via rear brake switch);
- Turn signal "blinker" relay;
- Turn signals (via turn signal switch);
- 7VDC regulator (for fuel gage);
- 12VDC regulator (for bike charger system);
- Stator coils (via regulator);
- Speed Warning Unit; and
- Changing Relay.
Lots of stuff in that circuit that could intermittently fail. Hopefully, this list will give you more to look at, and consider.
I haven't heard about intermittent regulator over-voltages, but maybe someone else will chime in. Have you checked the output of the charging system?
Also - if the fuse runs hot to the touch, you could measure the resistance through the fuse holder connections, and if found high, try re-heating/re-melting the solder joints at the fuse holder to get a low resistance connection.