One could make an argument that a drilled single rotor will fade quicker than a non-drilled rotor. Less mass takes less time to heat.
And many holes makes a bigger area for heat transfer. BUT Whether the new heat transfer area affects more then the decreased volume and therefor easier convection I don't know. Think you'll have to run some simulations and different cases to be really sure.
(Bigger heat transfer area > decreased convection or Bigger heat transfer area < decreased convection)
(hope you understand what I mean, English is not my mother tounge)
To answer the question: No, it doesn't matter if you made them identical. Is a wheel harder to spin clockwise or counter clockwise ? The wheel ( a circle) doesn't have a end, therefor no beginning, therefor no front or back
( you still have rotation direction on tires and such)