From what's been described so far, it seems like you might be starving for fuel under sustained open throttle/engine load......make sure the fuel flows to the carbs, (unimpeded high even flow), with the cap secured....(at 6k rpm cruise in top with good tune,you're burning probably 6 litres/1-1/2gal an hour)...sustained load always requires full fuel delivery rate to the float bowls.....otherwise, at high throttle openings while accelerating thru the lower gears, you can lower the float bowl fuel level and as you hit top gear you run out of sufficient vacuum to drag the fuel from the lower depths of the float bowls. CV carbs are even worse...they depend on vacuum (healthy firing engine) to hold the main needle open for even more fuel and more revs.