The CB450 can be just as reliable as the CB750.
The thing is, the CB450 is easy to screw up and cause major damage. Sort of like the CB125: if you miss an oil change, you can kiss that engine goodbye. Otherwise, it's damn-near bulletproof.
How to mess up a CB450 #1:
The CB450 needs its valves adjusted consistently. It's more trickier and less "approachable" than the CB750. The CB750 can be adjusted in an hour, tops without any disassembly. The CB450 requires pulling off two valve covers (likely wrecking at least one gasket) and removing the carbs and air box. The valves are adjusted using a turn rod that is located on both sides of the engine. There is a certain direction and tolerance that the flat head screw has to be. Not only do you have to make sure the valves are set to a very very small tolerance, but you have to pay attention to where the flat head screw ends up. If one didn't have knowledge of this, they could turn the screw past tolerance, and I could easily see major damage occurring. This is possible in your case.
How to mess up a CB450 #2:
The CB450 requires consistent periodic oil changes, like the CB125 (and probably CB350) because it doesn't have a replaceable oil filter. It's nice that you never have to replace it like you do the CB750 (and worry about having a spare seal on hand) but you have to put it back together properly since it's centrifugal. If you don't put it back together correctly, the top end won't get oil.