Let's review.
We have 4 identical cylinders fed by 4 identical carburetors. But, instead of having 4 throttles we have just one that actuates all four carbs at once. Given this senario, how well would you expect the engine would run if cylinder one was set for idle speed, 2 was set for 2/3 throttle, 4 was set to 1/2 throttle, and number 4 was set to 1/4 throttle.
Do you think all the cylinders would fire evenly?
This should point out the need for syncronization of the carbs. If one carb is set for a cylinder firing speed equivalent to 3000 RPM and the other 3 are set for a cylinder speed equivalent of 1000 RPM. The one cylinder is going to get more fuel than the other three, and you won't get a smooth idle, etc. etc.
If you can't or won't get 4 manometers to synchronize the carbs while the bike is running, I don't think you don't have much choice but to set them mechanically, so they are at least close.
This is not to say that there aren't still some issues with carburetion. If you weren't meticulous with getting all the passageways and orifices spotlessly clean, or you fed the cleaned carbs from a dirty fuel tank, there may still be some .016 inch holes that aren't flowing, too. But, for sure, all the carbs must be aligned if you expect all the cylinders to behave in the same way.
Oh, by the way, for your carbs, #2 is NOT adjustable. You will have to adjust the other three slides to open the same amount as #2. Further, if you are going to change needle clip positions, you'll have to resync them afterwards, anyway.
Lastly, carb tuning is last on the list of things to do for a major tuneup. Plugs, Points, timing, tappets, cam chain, and air filter must all be addressed before dialing with the carbs.
Be patient, take it step by methodical step, and it just has to run right. Physics, it's very consistent.
Good Luck!