The best I've ever gotten with the "middleweights" was with a '71 CB500. That bike regularly got 38-42 mpg and would hit ~125 miles before reserve.
The 550 that's being rebuilt for my STF2 bike only returned 26 mpg. It, coincidentally, was a '76 model. I know that there is NOTHING that should differentiate the '76 model from previous years, but I've heard others say that their '76 model has always suffered poor fuel mileage. Now, granted, that engine was tired and had started fouling #3 plug.....hence the current rebuild.
I had a '78 550K with a 562cc engine, ported head, CB650 cam, etc., and it would get an easy 34-36 mpg riding it however I wanted to.
The '76 550F in this thread has seen a BEST of 31-32 mpg after finding the upside down jet. It's been tuned to death; valves are right, timing is right, compression is good, etc., etc. Bone stock bike and carbs except for the drop in UNI filter and a Pamco.
I'll soon have another '76 550K on the road to compare. Same deal: bone stock engine, carbs, exhaust, etc., with a drop in UNI and a Pamco.