These engines are very modification friendly. there was and still is a huge market of parts available to do so. Hp mods and reliability are sort of inversely proportional. as you add HP you are going to effect reliability. What you need to do is investigate and find out more. satanic mechanic has a large amount of info and insight to all the different mods available and will put things into perspective a little.
http://www.webring.org/l/rd?ring=thehondasohc4web;id=2;url=http%3A%2F%2Fwww.satanicmechanic.org%2F In terms of "bored out" we need to know by how much are we talking a .025" oversize overbore or a 73mm 1060cc monster? It seems to me the most common over bore is a 64mm 811cc or a 65mm 836cc after that the $$$ increases drastically. If in fact its a 811cc or 836cc reliability really wont suffer all that much just a modest 10-15hp bump
In terms of cams its very similar to bore a low lift, low duration cam will have almost no effect or reliability while a big fat high lift, high duration cam will most definitely effect reliability. A lot of cams will be marked on the end of the cam, on the shaft of the cam or on the edge of the sprocket boss. Although some will be a mystery cam with no marks and all you can do is measure lift and duration and try to match the figures to known cam grinds.
In terms of setup all this performance stuff really doesn't have any major impact on setup. Your spark timing will likely still be setup same as stock and carburetors will just have larger main jets and needle clips lower on the needles.
The best place to start is to take a outboard spark plug out and have a look with a borescope or inspection camera.
Second place to investigate is to remove a tappet cover and see if there is special valve retainer gear,
Third place to investigate would be to pull a carb bowl and see what size main jets are in there, your F1 likely would have 105mains if you find 120, 125, 130's id say its likely you have a mild overbore like a 811cc or 836cc
Forth place is to pull the engine and remove the valve cover and inspect the cam for markings
Fifth would be to pull the head and cylinders for a look at the pistons and rods
here was the first hint of a not stock engine on my 750 2years ago.... Later i found out they were yoshimura 64mm 811cc pistons...