There's no real magic bullet here. Depends on how far you are willing to go:
>Conservative riding style. That means easy on the throttle when accelerating up to speed. This is probably the hardest part for me, since part of the fun of motorcycling is their rate of acceleration!
>Keep it tuned up.
>Final sprocket ratios are a compromise based on your riding conditions. Urban, stop and go traffic would be different than primarily highway/rural riding.
>Ceramic wheel bearings are expensive but offer the least rolling resistance...
>Go on a diet. You can even put the bike on a diet by shedding non-critical parts, or substituting lighter components.
>Supposedly non-o-ring chains offer less initial rolling resistance, but they require more maintenance.
>Always ride
downhill with the wind at your back!