Track your MPG and $/mi on either E10 or MTBE, whichever you have available, and compare that to MPG and $/mi on E85. With a fancy luxurious computer controlled vehicle MPG will drop appreciably with E85 but it's $/mi that matters, so track it and compare.
No E85 available locally but I've always build my engines to be close to the edge on 93 octane. Always thought it would be cool if E85 was available to build a real high compression street car.