Well, lacing a 50 spoke rim to a 40 spoke hub will be a trick. But I doubt that it will be "good to go" assuming that was a typo. I'm pretty sure you can make it work but there could be many issues. The axle diameter might be the same (check the bearing part numbers and see if those bearings are identical or have the same ID).
Fork leg spacing is unlikely to match so it's probable that special spacers will be needed.
I think the rotor mounting bolt pattern is different. The 350/400 brakes are not the same as the 500/550 so you have to figure a way for some combination of parts to work together.
Speedo drive is another interesting issue. I think Honda used different speedo ratios for large vs small displacement bikes, and I think they changed at 500cc but it may have been at 750?.