I actually have the same unanswerable question! Why did my all stock set up cb500 with new boots, rebuilt carbs & genuine keihin jets run rich at 0 to 1/8 throttle until I changed the slow jets from #40 to #35? (even without acetone in the fuel!) All I know is the bike is perfectly rideable ever since - around town it performs flawlessly but it hesitates slightly if I close and re-open the throttle at highway speeds (60+) - I can live with that, with the 'correct' size jets in it it really wasn't usable except for maybe on a race track where you could live without a working slow speed circuit.
If I were you, I'd go ahead and try the #38's!
John