Well, for a full blown race motor you will see a difference with going the 500 route, but then it would be working with a lot of other goodies to make it all work, headwork, larger intake valves, CR carbs, cam, exhaust, stronger rods, and you would probably be talking in the 13000-14000 rpm range.
For a good fast street bike I would go with the 466 yoshimura kit. Kevin in Seattle is building one at the moment, plus he is the importer of those kits, he can also supply you with the valves, valve springs, cams, CR carbs etc.
Kevin