Years ago, a group of us were riding our SOHCs and Z900s etc and one of my mates decided to stretch the legs of the borrowed 750 he was on - he wound it out to about 100mph and was some distance in front of the rest of the group, when we saw his arms thrashing from side to side and he veered off the road, hit a dirt mound, and launched into the stratosphere - result, one totalled borrowed 750, and one very sore and p'd off mate. It seemed his front tyre had gone down on him - er I mean had lost its air, without any warning or time to slow and bring it under control - scary stuff, and he's lucky to still be on the planet.
But I still think the look of spoked wheels are worth the downsides - safety, strength and cleaning etc.
Peter