I've been using 3.25 19 fronts and 4.00 18 rears on my 550s for 30 years. No regrets. I did try metrics out a while back. But, went back to inch sizes.
I think the stock rear was 3.75, 18 which isn't easy to find these days. (Or necessary, imo.)
The inch sizes are more apt to have the aspect ratio profile (100%) that was used in the suspension design, rather than metric sizes which use, at best, a 90% ratio. But, tire manufacturer do take liberties.
I've been happiest with Metzelers, so far.
Cheers,