I swapped the 1-4 and 2-3 plugs. The 1-4 plugs came out with the tips cleaner than when I put them in the 2-3 cylinders, and the 2-3 came out looking like a bad hangover after a short ride in the 1-4 cylinders. Am I right that this indicates that it's not a fuel issue, and not an issue with the plugs, but still with timing on the 1-4 pickup? Timing looks spot on.
There's another possibility, one that is rare (but happened to me!). I had a similar problem start happening in 2006 on my 750 while I was using it as commuter to-from work, half freeway and half surface streets. It ran fine until one day this same scenario started happening, fouling the 2-3 plugs in a single days' ride to work (44 miles round trip then). After a week of it (and running out of plugs!) it stalled on a 104 degree day in heavy traffic, acting overheated (but it wasn't), like it was boiling the carbs. This HAS happened before, but in Phoenix at 122 degrees with the Vetter lowers on, after a hiway ride into the town. This wasn't that.
After some investigation during cool-down, I discovered the spark wire was broken on the #3 wire, inside the jacket. The only clue was the extra-flexible bend it had when I was changing the plug. This un-balances the coil, making it misfire in certain RPM ranges.
Another similar coil-failure story: my brother came out here (Colorado) on his CB500 (Vetter with lowers included, circa 1976) and we toured the whole Southwest for a few weeks. On his way home across Kansas (alone), his bike suddenly started acting badly and would not run over 4500 RPM. It fouled all the plugs he had (#3 cylinder) with him. He bought new points at Wakeeney Kansas and installed them to no effect, then a whole points plate in Hays, same story. The bike would start and run OK, and when cold would rev up to about 7000 RPM OK, but after 1-2 miles of Interstate it would again balk, start backfiring and sputtering, and would not rev at all past 4500. He stumbled back home that way, taking 3 days to cross Kansas (and half of Missouri) to get home. When he got home he installed 2 new coils, and never had another problem with the bike for 15 more years.