Cleaning the advance will certainly help, but you may need to trim one or both of the advance springs ( one coil on each, then bend the spring over to form a new hook).
The mixture screws are on the air box side. They control air. Screwing them in decreases the amount of air, making the mixture richer. Screwing them out increases the amount of air, making the mixture leaner.
The exhaust is probably OK. Most 4-1 exhausts rarely require re-jetting. But we don't know what brand, so....
Your biggest issue is the pod filters. You just have to experiment, do plug chops, or find a dyno ("rolling road") and jet accordingly. There is no universal setting for pods.
Moving the clip on the needle up....towards the fat end... will lower the needle. That makes the mixture leaner.
Moving the clip down on the needle....towards the pointy end....will raise the needle, making the mixture richer.