Slim - I recently had a similar issue with my 74CB550 with the same 022A carb bank as yours. On my bike it was cylinder #3 that had a problem. I first thought it was a spark issue as the plug cap resistances were way off between cylinders #2 and #3, which can cause uneven spark delivery between the two plugs connected to that ignition coil. I decided to completely replace the coils and caps. When I did so I still had the dirty plug on cylinder #3 only, the remaining plugs were fine.....
I replaced the rubber intake boots, removed the intake manifold and replaced the o-rings to eliminate the possibility of an intake air leak causing my problem on cylinder #3. No change in #3 plug, still fouling.....
Re reading Hondaman's book chapter on carbs, he speaks of a problem caused by partial blockage of the air passage to the emulsifier tubes. On our bikes that passage looks like this:

...so off with the carb bank yet again to investigate further.
When I shot the carb cleaner into that passage on the #3 carb, it shot right back out into my eye! (don't let this happen to you). The other carbs had a clear path for the cleaner into the main jet cavity where the emulsifier tube sits. I had not been thorough enough in my previous carb cleanings....damn.
I used small diameter wire and the smallest size welding torch nozzle cleaner to clear out the passageway on carb #3 and the rest of the carbs for good measure, following up with more carb cleaner. When I buttoned her back up and went for ride afterwards, it was like riding a completely different bike - one with 4 working cylinders instead of 3! It was a good day, let me tell you!
Apparently if that air passageway to the emulsifier tube is blocked there is poor mixing of the air/fuel, which does not burn well, resulting in plug fouling. I had only the #3 carb with this problem so the fouled plug only on the #3 cylinder.
So my point is that perhaps your spark problem is not really a spark problem at all, which I think you already know. It might be an intake air leak or it might be a blockage of the air passage to the emulsifier tube. Or something else.....
Check those air passages to the emulsifier tubes - again. It sure made a big difference in my 550 with the same carbs as yours.
Good luck!