Synthetic creeps into places standard oils can't due to smaller molecules. However, the additive package is really the determining factor. It should have chemicals that soften the seals, so they seal better. Not sure this is true of all synthetics, or brands. Some have claimed that the switch made seals leak, for a while. But with time, the chemicals that soften seals eventually did their job and it stopped leaking. However, if the seals have been heated and aged for 40-50 years, they may be beyond softening, ... or it may take a while. I know that Honda HP-4 didn't make my 550's leak. Well, except the oil seals in the head. But, they weep a little regardless of the oil selection. It's just not bad enough to take the engine apart just for that.
Cheers,