https://www.enginelabs.com/engine-tech/fuel-cooling/clearing-air-ethanol-motorsports/https://www.enginelabs.com/news/4-things-not-know-e85-vp-racing-fuels/Don here's a link to some of EngineLab's articles on E-85. You've maybe seen some of these already.
I'm also sold on this fuel idea.
For me it started with the idea of having a 1/4" stroker crank and standard length Golden Rods, existing big-pin flat top Venolia blower pistons and a big valve open chamber head. You know, pretty much cobbling together a bunch of stuff that's been sitting on my shelves for years. And I like the better rod ratio, but once I did ALL the math (shout out to RBracing calculators
https://rbracing-rsr.com/calculations.htm) it was working out towards 11.5:1 static compression, and when combined with a minimal overlap turbo-friendly cam #'s there was just no cylinder pressure blow down. So now I'm having to look at fuel with a seriously high threshold of detonation, and you know it isn't cheap. The last time I personally ran 30+ lbs of boost with gasoline it was with ERC 118. And then there's the issues of boost pressure and heat, and - Manifold Air Density... (insert Gale Banks tutorial here)

Side note: Gale Banks is THE M.A.D Scientist (Manifold Air Density) The math and physics can make your brain hurt...
Due to access, for me it would be easier to get and way cheaper, but too much trouble, to use Methanol; the corrosion factor and required flushing kinda takes the fun out of it short of being at the track. And at 2.2 X fuel volume our carb, float bowl and jet options start to get limited.

So I spent some time reading and thinking about the E-85/turbo/high static compression engine street combo for a Saturday Night toy. Doubtful of using more than a tankful of fuel, and cans readily available from my local race gas suppliers. Very do-able.
Bottom line is get your fuel from a can. You can't trust what is displayed on the tag at a pump, for various reasons listed in these articles.