I have a 350F with open velocity stacks and open 4 into 4 meggas and I drilled my mains to #84's, up one notch on the needles and still playing with the air screws, but they are not that far from stock. Get everything correct as Honda would like it and then address the carb changes to work with your mods. The 350/400's seem to be picky when you start to mess with them, so you compound the problems if you change too many things (read: more than one) at any one time. If other things are not right, you are increasing the likleyhood that you will dowse the whole lot in gasoline and light it off, retiring to the study for a pint and a phone call to the insurance company. Being employed in law enforcement and having a wife who is an insurance adjuster...the aforementioned option is not one for me...(except for the pint(s!)). I venture to guess you will run pretty good with everything to stock (carb jets,float height, bench sync at least, lash, and timing). This should allow you to address the problems you may, or may have not (?) created by your pipe and pods. You might be surprised how close the stock set up might get you after everything else is done! Get it on the road and give it hell. If you have obvious problems, do some plug chops at that rpm range...there is some good stuff on the carb FAQ. Get it right and let us know.....