The shafts are supported at each end by the cover shaft bores. Those bores wear unevenly, allowing the rocker to Kant side to side. This makes the rocker cam follower and cam to advance wear where all the lobe pressure is now concentrated. They run quite some time in this condition. But, the longer it runs under this situation, the more wear occurs to both cam and cam follower, and this effects the ability for that cylinder to attain the same power as others. The increased wear usually means tappet clearance changes with the wear. I’ve not seen it, but it’s possible the larger gap can allow the tappet end to hammer the valve stem tip, making it mushroom, and damage the valve guide upon removal. So instead of just replacing the cylinder cover and cam you risk replacing or refurbishing the head, too.