My 40 Chev has 355", the double hump 71 heads, less compression than yours though, I built it for the street when good gas was hard to come by. Steel crank, pink rods, forged pistons, 9.5 or so comp. I had the old points distributor dialed in from a Hot Rod article. It's always run OK on whatever fuel it gets.
My gl may have low cylinder pressure, it's got 59K on it and sat for at least 20 years. I call it an "attached garage" find. That could be the cause of it's finicky tastes as far as fuel goes.