It entirely depends upon the media type the Blaster uses. Fine glass, Aluminum oxide, etc are good for stripping, easy to infiltrate any orifice. Taping off and blocking ports is about a 95% assurance. That last 5% could bite you badly.
Soda blasting is an option too. That media is more easily flushed. Vapor blasting leaves a "peened" finish and its lovely. The problem is, most vapor blast cabinets cannot manage an assembled engine. Great for parts, assemblies, but not so much for 150#+ lunks of metal.
If you dont want to disassemble, I'd recommend soda blasting. Easy to spray down your motor afterwards, and easy enough to flush out. Does a very good job at stripping withoiut so much abrasion as traditional "sand blasting".