Perhaps I'm not qualified to comment, as I haven't actually ridden my 500. But, I would be surprised if there was a significant difference in basic handling traits. It seems Honda didn't know about it either.
Item / CB500 / CB550k0 / Cb550 k3
Weight / 403.5lb / 423 lb / 426 lb
Whl Base / 55.5 In / 55.5 in / 55.5 in
Caster / 64 Degrees / 64 degrees / 64 degrees
Trail / 4.1 in / 4.1 in / 4.1 in
Fr tire / 3.25 19 / 3.25 19 / 3.25 19
Rr Tire / 3.50 18 / 3.75 18 / 3.75 18
So, it's basically a rear tire width difference, and an extra 20 lbs.
Now, what also changed was sprocket ratios, and the internal transmission gear ratios. Both the primary reduction and the final drive ratio was quite different. These later differences, while not frame handling issues, could certainly change the engine response feel going through the twisties.
One of the reasons why I hold on to my CB500 is because all the frame features (spares) appear to be the same as my 74 CB550. I haven't found any differences yet. Forks, yes, frame no. (The forks are different internally, external length and travel are the same.) But, I should probably add that I have not made detailed measurements, either.
Cheers,