If you are running modern automotive oil then yes your gearbox IS on borrowed time. Run any brand of oil you wish synthetic or not as long as it actually has this written out in the fine print on the oil container: "API rating of SG" and /or a "JASO rating of MA". API ratings of SJ, SI, & SH will do in your gearbox sooner or later. The phrase: "meets or exceeds all earlier API ratings" on a container of SI, SJ, or SH is not going to save your gearbox in this application. Post 1996 American automotive oils (SI, SJ, SH) have been stripped of their extreme pressure zinc & phosphorus base additive to make then more compatible with automotive catalytic converters. The gear faces in your bike's transmission need these zinc & phosphorus based additives to survive.
This topic always starts a long thread of responses called an "Oil War". Sure you have run you bike on Castrol GTX for thirty years now without troubles. Go out to the trash heap & find a 1995 container that held GTX. Compare the fine print to what is on a modern container of GTX. You may not have changed, but the EPA has changed your favorite oil. Knowledge is power: always read the fine print
Matt at PSB