are you running the right plugs with the correct gap?
I have a 78 F2 and I ran into what you are experiencing...
I did all of the tune up procedure in order and i runs like a champ now. If you do the valves, set the points gap, set timing (I went to a dyna), sync carbs and make sure all the boots are tight it should go away. If it doesn't I would say that it is your slow jets. Not sure on the turn out on the air screws, but I would run through all the tune up stuff and then set them all the way back and then put them where they are supposed to be stock. I thought I had it all nailed down, too, but a few of my boots were a tad leaky.