I too am having a similar experience (got an 81 CB650C for $200). When I got it in July I checked everything but the carbs (friend had cleaned them last year and I added seafoam to the fuel), new battery, new front tire, brakes, fork oil, oil, air filter, plugs. It ran really good for the first 7 miles... Then it started running rougher and rougher. At the end only the number 3 cylinder was running. The plugs were oil fouled, and the carbs seemed to be running way to rich. After reading up on this forum, it looks like this is a common problem on the 81. There was so much raw fuel lying in the #2 exhaust that it was burning orange down by the bridge pipe between #1 & #2. I currently have a set of 82 CB650SC carbs (purchased on ebay... I have never seen such nasty debris and crud in a carb before) on my bench at home and am in the middle of a complete rebuild, kits are on the way from sirius.
The other problem that I found was that my new battery was dead, even though I had only put 8 miles on it, and had kept it on the trickle charger. The autoparts store tested it and replaced it free of charge. With new plugs and battery it ran half decent, for a mile... before fouling the plugs again. I hope that after the carbs are rebuilt it will run like it did for the first 4 miles...