My wife is driving a 2000 Toyota Sienna. Has maybe 110,000 miles and doesn't use any oil or sound appreciably different than when we bought it with 35,000 miles. What has broken:
Exterior door handles. May have a lot to do with three small children yanking on them while they are still locked.
Drivers side power window stopped going up and down properly. Replaced and no more problems
Right rear brake drum went out of round and was replaced.
Did a service at 85000 miles to replace belts and hoses etc...
What hasn't been a problem:
No radiator problems
No engine problems
No trans problems
No problems with alternator, starter, or power steering or A/C
For reference, prior to this vehicle (and the third child) we drove a '96 Chevy Blazer. It was a piece of crap. Alternator failed before the 50k mark. The engine used oil from 28,000 miles onward. The A/C went out around 55,000 miles, Brakes wore out real quick. Noise of the engine (4.3 liter) was loud on cold mornings. A/C drain line stopped up and flooded the passenger floor which led to an awful smell even though we pulled the carpet out and dried it. It would run like a scalded dog though which came in handy one night taking my year old daughter to the emergency room after she locked up from a bad reaction to a drug.... another story.
Back to the Toyota - Oh yeah, we took about a 2000 mile trip across the southern U.S. - Birmingham to San Antonio, to Roswell NM, to the Grand Canyon to Denver to Steamboat Springs CO to Nashville to Birmingham shortly after passing 100000 miles. Had zero problems. With all the gear inside and on top and in the altitude of the mountains, it spent a great deal of time in the 4500 to 5500 rpm range and occasionally stayed between 5500 and 6000 rpm above 7000 feet (where it was short on power) on long inclines. It never overheated or got spongy on transmission shifting. It would finally shift back into a higher gear and slowly lose speed until it would kick back down. I was pushing kind of hard due to following family in a Toyota with a V8 all around Colorodo. Didn't use a drop of oil.
I highly recommend it. However, Toyota issued a warranty extension to 100,000 miles due to a "transmission stops working" scare on these models, so you might do some research if you are interested in this model. We change our oil at 5-7k miles and don't seem to see much discoloration of the oil. Whatever the quick change place throws in it has been good enough.
And that is more than .02 worth!