I haven't calculated my CB550 mileage in a good long while. And, since retirement, I don't drive a regular route anymore, and I don't stick to one bike either.
When I bought my 74 550 in 1975, I recall the PO proudly and exuberantly stating the bike got 50 MPG on trips he used to take before he wrecked the bike.
Because of the wreck, I put 4 into 2 exhaust on it to make it road worthy for the least cash outlay.
It was my only bike for many years and my mileage, when I used it for commuting 17.5 miles away, was about 45 MPG with a 50/50 mix of 70-ish MPH cruise and 25-30MPH stop and go. I didn't keep good records. But, I recall refilling the tank about once a week. I'd drive it to my usual gas station, near home, after I switched to reserve. The 74 550 has a 3.7 gal tank. 35 miles times 5 days with say 3.5 gals of gas is about 45-50 MPG.
When I put the big Vetter fairing on it (6 AM rides in January were, too cold) I thought the mileage would get worse. But, I didn't notice any change in fill up frequency. This surprised me. But, it makes sense because with the Vetter, I felt air pressure on my back instead of my chest, though at a reduced magnitude. I speculate the big Vetter actually improved the bike aerodynamics, offsetting the added weight.
Anyway, when I started riding the F models with the bigger tanks, I found I could go longer between fill ups. So, I believe with their stock pipes and uni filters in the stock airbox, they get at least as good gas mileage as that old 74. But, that's without any real numbers recorded.
I went on a ride with other club members a few years back. We rode for the day and I was using my 77 CB550F for this ride, and my wife was on the back. The group, led by 750 riders, of course, all pulled into a gas station, so I followed. I hadn't switched to reserve yet, but I figured while I was there... Anyway, I filled it up, and the 750 rider next to me noticed final amount. His incredulous comment was, "That's all it took!?". We'd both ridden the exact same amount and filled just before the outing. We were both riding two up.
My 78 Cb550 hasn't gotten the regular use my others have had. (Which is why I'm selling it, btw) But, when I WAS riding it, it sure seemed more frugal than the others with gas. It also doesn't seem to have the power the other have, though, either. I suspect the stock 4 into 4 exhaust is the cause for both the fuel economy as well as the power anemia. But, it's just a feeling I have. No data from controlled testing.
FWIW
Cheers,