Well it's not so much that the SOHC bike is more reliable Greg, (everything below the cylinder head is of a similar design) the DOHC engines produced a fair whack more BHP than their SOHC parents, and so were more stressed.
The main problems (that I'm aware of, at least) were seized cam chain adjusters, (there were two adjusters from memory, one at the front and one at the back of the cylinder block) "weak" bottom ends, (plain bearing cranks like ours, and easily damaged if regular oil change intervals were ignored) and dodgy ignition modules.
They were still far more robust than the early VF750 and VF1000 V4 engines which were absolute dogs, it's amazing how Honda was able to build something as magnificent as the SOHC CB750, and then take 10 steps backwards with several models which all but destroyed the company's reputation for excellence in engineering.........
They certainly aren't as "collectible" as the earlier SOHC bikes, but if your mate has found one that's in good original cosmetic condition and looks like the engine's been looked after, (stay away from rattley engines that will need a top end rebuild) then he should buy it. Just make sure he gives it an oil and filter change as his first priority! Cheers, Terry.