Dont use an impact wrench on it while its in the cases. You'll be hitting against the shift forks and such and you'll damage them.
You can leave it in. Does NOT need to be out to split the cases.
Drill off the head and replace the screw if it bugs you once you have the cases split and the drum in your hands. (careful to get the birdcage back together properly)
Set the new screw with some blue locktite, and stake and edge so it wont turn out
Welcome to the forum, btw.