Yeah, the hi-vo chains are a lot stronger than roller chains, but as JL mentions, there's a fair bit of work (and a lot of money) involved, too.
Personally, if you're building a sub-100 BHP engine, I'd say stick with new OEM primary chains and a Tsubaki cam chain, with an M3 racing camchain tensioner assembly and your engine will be as reliable, as it is fast.
If you're building a 1000+ cc engine with over 100 BHP, I'd use the CB900 or CB1100F crank with Hi-vo (primary and cam) chains. If I was building a drag bike, I'd use a much modified CB750A engine, with that 2 speed auto. "Horses for courses". Cheers, Terry.