I was at the same dilemma when I decided to rebuild my 750 F2 engine. I saw many threads about the F2 head and the problem with valve guides wear. I thought about swap the head by a K head, but it was not easy for me to find a K head. Also, I didn't know if my F2 camshaft would work on a K head. Due to that, I decided to buy new guides for the F2 head, new valves and to keep the stock F2 head.
Buzz, at Dynoman, told me about the problem of the lash on the valve stem, and that installing titanium spring retainers instead of the normal retainers would prevent the valves to lash and, consequently, they wouldn't wear the valve guide. Also, I installed Kibblewhite guides. But i think that it only would help with new valves, because, as Buzz told me and as I saw looking at the valve stem, the top of it had some scores due to lash that happened on the past.