If you're talking about the old-style vertical twin - absolutely reliable. That is probably one of the most over-engineered engines made. The Japanese set out to copy the British 650 twins of BSA and Triumph. They accomplished a much better engine with good electrics, good reliability, and no oil leaks. Parts are widely available and both of mine have been among my all-time favorites to own, to work on, and to ride.
Just so you know -
1) They make a lot of torque, but only about 50 horsepower
2) They shake like crazy over 4,000 rpm
3) They shake like you're insane at their 7,500 rpm redline
4) They will go from 15 mph to 100 mph in 5th gear. You will be amazed at how this engine loves to "grunt". Gear changes at 1,500, 2,000 are purely routine.
5) Did I mention they shake? At idle, on the center stand - they will go backwards when you give them throttle. I'm not talking the tire - I mean the entire bike will move on it's center stand and go backwards - its one of the strange traits of the 650 Yamaha twin.
Seriously though, it is my 2nd all-time favorite bike (my 1973 is now and my 1977 was years ago). My little CB500 Four comes in first.
You can't go wrong for 350 -
Gordon