If the rocker cover will come off with the engine in the frame, then yes. It looks like there's room and the 400F cover comes off easily, so it should. The front blade (the guide) is then free, the rear one (the tensioner) is held in by a bracket with two 6mm bolts.
There's a rubber block in the bracket that the tensioner blade pivots on. The main thing to be careful about is not dropping the bolts, bracket, or block into the crankcase.
Once you have the top off and remove the bracket, undo the tensioner lock bolt and see if the internal mechanism is free. You should be able to push the rear blade down and have it spring back up with no problems. Any problem with movement means either living with it or splitting the main cases to get at the parts. Press the rear blade down all the way and lock the adjuster, this makes installing the blades a bit easier. Getting them in and seated correctly is a bit fiddly with the frame in the way but it can be done, mostly the problem is that you can't see down at what you're doing.
The rubber block has a notch for the blade to seat into. It isn't exactly centred but I haven't seen any instruction as to which way it goes... probably it doesn't matter but try and take a look at it when it comes out and get it back the same way. It might come off with the bracket and might stay with the blade when you lift the bracket off.
Use some medium (blue) loctite on the 6mm bolts. You need to clean the oil off the threads and out of the holes for it to work properly.
Loosen all tappets and ensure that none are stuck on a valvestem when you reinstall the rocker cover! Be very very careful with the rocker cover bolts, get them back in the same holes they came from (you want the right thread engagement - mixed up will have some too deep but not a problem unless they bottom out - and some just holding by a few threads... guaranteed to strip) and tighten with great care. The head threads strip easily! Loosen the adjuster lock once the cover is on, and slowly rotate the engine forward a turn or so. Lock the adjuster and it should be tight enough to start and check for noise. Maybe the adjuster springs weaken with age or something, but several 400s I do work on need manual pressure on the adjuster rod to tighten the cam chain enough so the motor doesn't sound close to self-destruction. Set the tappet clearances and you're good to go.