The twin you don't hear much about is the one they made the longest, the DOHC 450. Came out in '65 (?), got a 5 speed trans. in the late sixties, ran until '73. Then it got a makeover as a 500 twin and ran '74 to '76(?). Not positive on the dates but they made it quite a while and it is a great compromise between the benefits of a twin and a four. It is as tall and steady as any of the fours, so you don't feel like you're dwarfing the bike. It has the ease of maintenance of a twin, but most of the power of a four. I had one for a while but it came down to a choice between it and my 750 and I kept the 750 but it really was a tough choice. There's 5 450s on Ebay right now ranging from $800 to $1900 and 4 of them look great.
The fours of this era are built more like modern engines and are longer lasting. The twins all ran on ball bearing mains, roller bearing big ends on the con rods, and piston style oil pumps with centrifugal oil filters. The fours ran on plain bearings (mains and rods), had rotor style oil pumps, and cartridge oil filters. This made the four cylinder engines generally much longer lasting than the twins. Maintenance costs are a little higher on the fours just because of 2 more spark plugs, the occasional set of carb kits costs twice as much and they hold a little more oil, but it really is negligible in the long term. Buy what you like and enjoy it.