You may want to consider UHMW for the slider part.
Plastic has it uses, but I have run into situations more than once where a plastics company has all but guaranteed they had the solution, only to end up with worse performance than original material..
All that you say is true. There is an old saying, "Those who know plastic use metal." If a plastic part design is copied directly from the metal part it is intended to replace, it already has roughly an 85% chance of failure...
The UHMW (Ultra-High Molecular Weight) materials will have better wear resistance. Delrin 10 would be a candidate here. There are also other grades you could try: Delrin 100KM (Kevlar fiber filled for abrasion resistance), or Delrin 100AL (Advanced lubrication for friction).
However, I wouldn't use Delrin inside the engine. The temperatures run too close to the normal working limits of the material. When working with semi-crystalline plastics like Delrin POM, you not only have to consider the melting point of the material, but other factors such as the HDT (Heat Deflection Temerature) and Glass Transition Temperature, etc. Heat Deflection temperature is what the name implies- the temperature at which the material delfects easily at a certain load. Glass Transition Temerature is the point where the non-crystalline portions of the material start to "move around" on the molecular level, altering the material properties. Even in water-cooled engines, Delrin is not used inside. Delrin was tried for various underhood applications in cars years ago for clips, etc. and they all basically turned to dust and disappeared in the elevated temperatures. Glass fibers can be added to polymers to stregthen them and improve their high-temperature properties, but when the outer "skin" of polymer is worn away, the glass fibers become exposed and wear away at the metal riding against them.
Most automobile engines use unfilled Nylon 6/6 for cam chain guides. Another alternative would be a product like Zytel HTN polyphthalimide, or Vespel Polyimide (they use it to make bushings for jet engines!) however that stuff is mucho expensive...