As having owned CB/CL350 twins, 350f, and a 550 I have a couple observations.
The twins (including the 450/500), are great backroads bikes. Very torquey and fun to blast out of turns. I really like the "scrambler versions". But they are not near as smooth as the Honda 4's. And also seem to lack oomph on the highway.
The 350f is a great around town bike. Nice and smooth, and has one of my favorite exhaust notes (it gets addicting). It's the swiss watch of the old Hondas. It revs pretty high over 50mph, but you don't really notice that much. But it would not be my first choice for a highway cruiser.
The 500/550's make up for what the others do in power. But it seems to lack the character of the others. It'll cruise on the highway and tackle the backroads. A great all around bike, even if it doesn't have a lot of panache.