bmw thinks a shaft drive can handle 200 mph otherwise they would not have put it on the k1200s. However if you have seen the size of the k1200s shaft the thing is like a car driveshaft in size.
The reason I don't think the shaft is a good idea is because of shaft jacking. BMW, kawasaki, and others employ very high tech suspension systems you limit the transfer of this to the chassis, something that I think would be too complicated to work out given your bike's specalized nature.
Instead of a convention suspension, what about an airbag suspension? That way you can adjust ride height and suspension rebound while you are moving. I don't know how you would do this with a conventional fork so maybe an earls fork design with twin airbag shocks upfront and a single airbag monoshock in the rear. it could be done with a small onboard compressor on a streetbike (they make them for harleys that run air suspension) or with a good sized bottle if this is to only be a racebike.
I see your point about the shafts. Hmmm...
As for the suspension, what about a girder design? Would retain side to side rigidity but still be able to benefit from an air based suspension. Or BMW's telelever thing or whatever it's called.
I am definitely on board for the rear air suspension. Given the practical applications on cars and HDs that should be easy to modify to suit my purposes.
So here's what I have so far....
Aerodynamic body work (a given factor) from carbon fiber.
Air based suspension.
Carbon fiber wheels (thinking from a busa or zx-14 based design)
I was also looking at adapting some motogp carbon-carbon braking systems (heavy heavy but wow)
Transverse inline-4 (for keeping things as slim-lined as possible.
Two or three speed transmission (leaning towards 3 speed for minor driveability in the pits)
Chromoly frame (or aluminum or whatever will support this beast)
In an effort to keep things as light as possible, I would be willing to dip into my Ti supply that I was going to save for my CB750 build. Maybe a Ti frame?
Everything kind of depends on engine and trans length.
I currently have a 93 GSXF600 Katana engine that I could cut up for a donor. But maybe something bigger?
I need to dig out my parts books and manuals for the henderson and see how they laid it out. Maybe I can make something more robust.