On the 1978 the adjystment screws are actual mixture screws not air screws as in pre 77 carbs. The needles are fixed, but can be shimmed if you understand why you are doing it. That will only effect the motor up to 1/4 throttle or less. My bike came with 110 and the PO had moved them up to 120 without changing exhaust or airbox and while I am a tad rich, I like the way it runs.
After market exhaust and pods change the engine breathing. I would sugget you search on Pods, you will find a lot of info on making them work well. If you change carbs, you are walking down a road you may not to go down. It gets more complicated.
Do a search on PODS and you will learn everything you will need to know.