well, i've built a '68 bonneville, '79 kz650, '74 rd350, all pretty close to 'perfectly tuned' (with my bike mechanic pals back home mentoring me along the way), so my seat-of-the-pants can kind of tell me when something's right or not. having rode my bike in both rich and lean carb conditions, i can feel the difference. i know my bike's off because when i'm at WOT under load/against wind on the freeway, i hit a wall around 8500 when it should want to rev to 10k.
but i ordered some smaller 159-type needle jets, as my initial install of the enlarged 176's is still not right, although i didn't have a lot of time to mess with variables. so i'll likely go your route, with smaller 159's. knowing the way my bike is running with P-5's, i doubt i'll end up with a P-0, but you never know!
i would, however, disagree a bit with your assessment that it's ALL about load and throttle position. i think you have to run through the entire range of throttle with these carbs (or put the bike on a dyno) to really know if you've got them dialed in.
but at the end of the day, it's all about what you want from the bike. i want a bike that i can ride around town AND ride long distances at prolonged high speeds. whether it's out to the hill country or dallas via freeways, or on the track.
to that end, i've had my engine apart for a complete top-end rebuild, and i'm in the process of replacing/refurbing every component on my bike. engine (overbore/new valvetrain/headwork/exhaust this winter), ignition/charging, suspension, brakes/wheels, etc.
best of luck and good riding!