I used a Throttle Boss which clamps to the end of your throttle grip so that you can use your palm to maintain a steady position. On a long trip my brother and I did between Eureka, CA and Sacramento, about 330 miles, my right hand kept going numb and was very uncomfortable. On a later trip of about 150 miles I didn't use the Throttle Boss. No numbness, and my wrist wasn't tired. I know some older riders will take off the throttle return spring for longer trips, relying instead on the push-pull action of the cables to close the throttle slides. I may try mounting the Throttle Boss inboard of the grip instead of on the end, but I have a feeling the numbness will return.