Fuel delivery is a gravity feed system. It should be plumbed so there is a constant, drop between source and destination as the only pressure that pushes the fuel through the line is generated by gravity on the column of fuel directly above the fuel tap on the tank and the fuel in the drop between tap and carb inlet valve. If any of that fuel has to rise back up, fighting gravity, this subtracts from the fuel pressure on the carb inlet valves.
Air can and will get into these fuel lines an those "bubbles" will try to reach the surface of the liquid (normally inside the fuel tank). This creates back pressure. More air means more back pressure. And, particularly when the fuel level in the tank is low, less fuel pressure and flow that makes it to the carb inlets.
Honda put a fuel filter in or before the fuel tap for a reason that few seem to understand.