Dunno about the 350, but Piper did make a 16 valve head for the 750/4, I remember seeing one (incomplete) at an autojumble some years ago & looked into it. Apparently they made very few, for racing, and they weren't very successful.
There were also Piper exhausts in the UK in the 70s/80s, presumably the same company, similar to an Alfa (which in turn were a cheap Yoshi-type system) but the tailpipe was much longer. Very loud too, I had one & remember a mate hearing me miss a gear when I was about 4 miles away from his place.