nothing wrong with trying that but essentially you will be multiplying loads on all transmission gears/chains X2.
with stock firing order, torque load at any given time equals the force of only one cyl, with a big bang I-4 you will get two bigger torque peaks rather than four per engine cycle.
the yamaha crossplane is not a real big bang, the idea there is to keep crank speed more stable to improve drive control. By the way, Helmuth Fath tried it way before yamaha in the 60's in his 500cc GP sidecar motors.