This isn't so much about selecting the bearing sizes (that's been beaten to death here at the forums) as it is about the details surrounding their clearances and construction.
When Honda made the cases on these Fours, they finish-machined the clamshell halves and torqued them together without any sealant in the interface. The bottom of the engine was pegged in place using the 2 little "drain plug" holes on either side of the bottom cases (on the 750), which are now plugged with small drain plugs (that leak from hard O-rings after 40 years...). Then they clamped the cases down with approximately 2 kg/m of force and align-bored the 5 holes for the bearing seats. This situation creates the "original round hole".
As the cases cure from years of heat, they shrink a little from front to back. The crankshaft pushes downward on the bearing seats in operation: between these two factors the lower half gets ever so slightly egg-shaped, big end down (about 0.0002"). In most engines that have had good oil and haven't spent time on a racetrack (i.e., extended high-RPM loads), the lower bearing is the one that wears. Honda knew this from the beginning, so like the points that first came out (moveable part of the points only), they sold the bearing shells in halves. In Japan, their mechanics were trained to replace just the lower half if the clearance was getting big, to save $$ on maintenance and give Hondas a good overall reputation for low maintenance costs.
When you are Plastigaging your bearings, if you have the time, gage both top and bottom of the bearings and you will see the inequality of the wear. If the wear is still within spec (i.e., less than 0.0032" worst case) you may find that just the bottom bearing needs new. I have seen this many times. If your crankshaft is in good condition and not worn in the journal at this site, replacing just the bottom half with the same color bearing as the top half can provide a good "budget rebuild" for you. However, if you are planning on spending a lot of time near that redline, replace both halves so the bearing crush zones will align perfectly upon case torquing: this will ensure even oil distribution to the top half of the bearing.
If your journal is worn (evenly) you can gain like-new smoothness by stepping down one size in clearance from the original bearing. Each step is (in English) 0.0004" smaller, and this action requires that you replace both halves at once. Break your engine in for at least 1000 miles below 5500 RPM if you install (a) tighter one(s): it will be like brand-new at that site and needs some time to polish the bearing and crankshaft interface.
If the journal is not worn evenly, and removing the taper will still net the proper clearance for the BLACK bearing shells (smallest), then you can save the crank and still get like-new performance. If you have to leave a little taper in the journal but can get at least 75% of it flat and even (and aren't going racing), it will still be a very long-lived engine, because a 5 main bearing bottom end under a 45 cubic inch engine makes it like a tractor bottom end, able to leap tall buildings in a single bound.
When Honda originally assembled these engines, the case contact areas around the bearings did not receive sealant. This allows the area directly around the crankshaft to pull inward slightly more than the rest of the case, which prestresses the whole assembly to stiffen it more around the crankshaft and helps mitigate the extra clearance from the upcoming case-cure cycle (which won't happen to you this time, BTW). So, when you assemble the cases, always start with the big 8mm bolts first, fully torqued. Then install the center 6mm bolts next, torquing them from the center ones first, to about half the final value (50 inch-lbs) and then to their final value (90-100 inch-lbs): 3 steps is better. I usually torque the ones across the front of the cases last: this seems to keep them dry there longer over the miles. Be sure the engine gets at least 24 hours of drying time before putting oil in it, or it will develop leaks from washing away the edges of the uncured sealant on the insides (which is why so many racing engines leak: 30 minutes between application and startup!).