Eurban: I agree with your points.
On the CB750 (in line 4 with 180deg crank, 2 pistons up, 2 pistons down at all times) the breathing in and out is much more neutral than say a twin with a 360deg crank. And with ring blowby, its slightly positive virtually always. Hence I say attention to sucking likely not an issue, but a filter on the end of the tube can't hurt.
Upon deeper reflection, yes the bikes I'm thinking of, my HawkGT for one, routes to the airbox first, and then to the drain tube which is plugged for periodical draining.
All performance Hawks have highly modified airboxes, or more likely pods, which Dyno runs prove are more efficient than the stock airbox, at least for HawkGTs, the emmissions breathers are routed to catchcans. I'm not sure if filters are used, there is a large sucking force in the crankcases as 2 pistons travel nearly together.
I like camn's idea of routing the hose into one of the pods. If the engine is healthy, little internal blowby etc, this shouldn't be a problem. One could even T it and run it into 2 or more of the pods, to spread out any ill effects.
To each their own.