Plug fouling was a mark of the 1969-1972 CB750s. It was due to 2 things:
1. Honda was scared to death of burned up engines in abusive American hands (for good reasons, as it turned out!).
2. Japanese gasolines don't carry the octanes like American fuels, making for some unusual tuning.
Things are quite different today, obviously...
To reduce the fouling on those bikes, take the first step and drop the mainjet a little. You'll find it to be either 120 (1970 tuning) or 115 (bikes made between about 9/70 and 5/71). The K0/K1 today can benefit from using the 110 mainjet and the modern versions of premium fuel, especially Shell/Phillips fuels.
If that's not quite enough to stop the fouling, check your needles: if they are in the center clip, then lower them one notch (raise the clip) and go back up a 5 step on the mainjet. By the time of the HM341 pipes (more restrictive than those original HM300 mufflers), the standard tuning became 105 mains with the 4th notch on the needles. This dropped some 5 HP at the rear wheel at high RPM, though.
One other thing: does yours still have the HM300 fiberglass-pack mufflers? If someone has substituted the HM341 pipes and left the original jetting in place, you won't be able to keep a plug clean for nuthin'...
One last thought: after the years passed, the (soft) seat for the little air screws on the carbs have often become slightly enlarged from owners tightening the screws too snugly when readjusting them for their 1 turn setting. This will make the 1 turn setting run rich, like it was at, say, 1-1/8 turns out. So, try setting the screws at 7/8 turn or so. Mine are at 15/16 on 3 cylinders, 3/4 turn on one of them, for foul-free riding.
If you decide to go Saturday-night street fighting, set the air screws back out to 1 turn or a hair more for the evening, for a temporarily better launch.
