If you want to ride in formation through town on your way to the bar with a bunch of guys wearing leather vests and do-rags, then buy the VT. You'll fit right in and fall into the pit of anonymity. It is about as interesting as an insurance seminar.
If instead you would prefer some high speed long distance touring and canyon carving with some friends that have actual riding skills, then buy the ST. It is a fun, comfortable mile eater and the V-4 mounted in that configuration is a really interesting departure from the norm for Honda and it works great. A friend of mine had one several years ago and I always enjoyed putting a few miles on it for him. I actually wanted one when I was looking for a replacement for my BMW K100RT. I could have bought about a 2001 model for around $6,000 to $7,000 but I found a 2004 Kawasaki Concours in great shape with only 25K miles for $3,500. I've been pleased with the Concours but would I would have bought an ST if they weren't so pricey.
Either the VT or ST should be very reliable.